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Case Study: Occupational Asthma

 A 30 year old male with asthma and exposure to Western Red Cedar. He had no past history of asthma. He commenced work in 1986 as a glazier in a firm manufacturing windows and doors. His workplace was one open factory; wood machining, wood joinery and glazing were carried out in adjoining areas. His job involved cutting glass and placing glass in windows and doors. Almost all of the wood used in the factory was Western Red Cedar.

 Within 12 months of commencing work he developed rhinitis and dermatitis. During 1994 he noticed the gradual onset of cough and chest tightness. His GP diagnosed asthma and commenced him on beclomethasone and salbutamol. In 1995 he left his job as he felt his asthma was work related. Between 1995 and 1997 he worked as a courier. During this time he ceased all asthma medications and had no asthma symptoms. In October 1997 he recommenced work as a glazier in the same factory as previously. Within one month he recommenced asthma medications because his symptoms had recurred. His asthma has persisted since and has become worse in the last year. He has had had two exacerbations of asthma during the last year requiring courses of prednisone. Triggers to his wheezing episodes include exercise and upper respiratory tract infections. He doesn’t recall any spills or accidents at work. He had a 5 pack year history of cigarette smoking and has not smoked for 10 years.

 His examination was unremarkable and his baseline spirometry was normal. He had evidence of non specific bronchial hyper responsiveness with a positive methacholine challenge. He monitored his serial peak flows and the results are shown in Fig 1. There is a significant deterioration in his peak flows at the start of the working week with an improvement on the weekends.

 

 

Figure 1. Serial Peak Flow Measurements

 

A diagnosis of occupational asthma due to Western Red Cedar was made. He was moved to another part of the factory with no exposure to western red cedar and now has no asthma symptoms, is on no medications and normal methacholine challenge.

Important Points

  • New asthma in a working person means a careful occupational history needs to be taken.

  • Occupational exposure to a known cause of occupational asthma increases the likelihood of the diagnosis of occupational asthma.

  • Work related symptoms including rhinitis and dermatitis followed by asthma symptoms are suggestive of occupational sensitisation.

  • Evidence of non specific bronchial hyper responsiveness confirms the diagnosis of asthma.

  • Evidence of work relationship documented with serial peak flows confirms the diagnosis of occupational asthma and should be done before advising worker to cease exposure.

  • Exposure ceased and symptoms and non specific bronchial hyper responsiveness has resolved.

  • Further exposure to Western Red Cedar needs to be avoided.